Recent advances in multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, cytometry and imaging, in combination with bioinformatics and biostatistics, have been translated into several popular bioanalytical platforms, such as next-generation sequencing (NGS), single-cell analysis, flow cytometry and mass spectrometry. These platforms, although widely adopted, require tissue fixation and are therefore not capable of providing fundamental information about cellular interactions and biomarkers quantitative assessment. Furthermore, several live cell imaging and non-destructive fluorescence histological methods measure limited number of biomarkers at a time and the tags introduced may interfere with the natural function of genes and proteins. As a result, industry and non-industry stakeholders, are on the lookout for advanced platforms that can simultaneously capture the arrangement of multiple biomolecules (DNA, RNA, proteins and others) with single-cell or subcellular resolution. The up-and-coming field of spatial genomics in biology promises to bridge the gap between high plex, high throughput, and high resolution. Currently, several stakeholders are engaged in offering integrated solutions (platforms, software applications, services) to perform tissue analysis and spatial phenotyping, across the full continuum from discovery through translational and clinical research.
Presently, over 45 industry and non-industry players across the globe are engaged in the development of spatial omics solutions for spatial phenotyping and profiling of cellular landscape. These spatial solutions can support variety of tissue samples and can analyze different biomolecules such as DNA, RNA and protein utilizing multiple modes of imaging. Examples include CosMx Spatial Molecular Imager (NanoString Technologies), MERSCOPE platform (Vizgen) and PhenoImager- Fusion (Akoya Biosciences).
Majority of the collaborations 21%, inked by stakeholders in domain, were focused on the commercialization of spatial omics platforms / technologies. Examples of recently signed commercialization deals include (in reverse chronological order) collaboration between S2 Genomics and Mission Bio (April 2022), Ultivue and Standard BioTools (August 2021), 10x Genomics and Advanced Genomics Core (October 2020). The growing interest of spatial omics solutions providers to diversify their products portfolio and enhance the abilities of their existing instruments, has led to several deals inked for the integration of spatial omics solutions with the contemporary staining assays / reagents. In fact, platform integration agreements account for 18% of the total deals inked in this domain, since 2016. Examples of such instances include (in reverse chronological order) partnerships between Ultivue and Keen Eye (March 2022), NanoString Technologies and Leica Biosystems (February 2022), and Akoya Biosciences and PathAI (December 2021).
During our research, we estimated the market under conservative, base and optimistic scenarios. As per the base case forecast scenario, market for spatial omics solutions is estimated to be worth over USD XX billion, growing at an annualized rate of XX%, in the given time period. The opportunity is likely to be well distributed across type of solution, type of sample, end users, research areas and key geographical regions.
For additional details, please visit https://www.rootsanalysis.com/blog/spatial-genomics-and-proteomics-solutions/ or email sales@rootsanalysis.com
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